About Us
Founded in 2019, Shanghai Juncell Therapeutics Co., Ltd. (Juncell Therapeutics) is a biotechnology company focused on the research, development and commercialization of cell therapies for the treatment of solid tumors. Leveraging our proprietary DeepTIL™ Cell Enrichment and Expansion Platform, NovaGMP™ Non-Viral Gene-Modification Platform, and RiverTIL™ In Vivo TIL Platform, we innovate at the source to enhance product efficacy and safety, and significantly reduce production and overall treatment costs to improve TIL therapy accessibility.
Focused on high-incidence tumors and hard-to-treat tumors, we have developed a pipeline of first-in-class and best-in-class autologous natural and gene-modified TIL therapies, covering adjuvant early treatment to later-line advanced therapy across multiple disease stages and treatment settings.
GC101, is the world's first TIL therapy that does not require high-intensity lymphodepletion chemotherapy or the use of IL-2 administration. Expected to be China's first approved TIL therapy, it provides sustained clinical benefits to melanoma, NSCLC and other patients who have failed multiple lines of treatment. GC101 registrational Phase II clinical data results have been included in the latest breakthrough abstract by the American Society of Clinical Oncology (ASCO) .
Core Technology
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DeepTILTM Cell Enrichment Expansion Platform
☛ Clinical-grade TILs can be obtained with a high successful rate.
☛ TIL cell culture does not rely on healthy human PBMC as feeder cells, resulting in a simpler process and lower cost.
☛ Free from high-intensity lymphodepletion chemotherapy and IL-2 administration, and patients can be treated in less demanding wards, with improved safety.
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NovaGMPTM Non-viral Gene Modification Platform
☛ Non-viral gene modification. No risk of wild-type virus mutations.
☛ The cost of non-viral vector-based gene modification is substantially reduced compared with that of viral vectors system.
☛ Average gene modification efficiency >45%, Average viability after modification >90%.
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RiverTILTM In Vivo TIL Platform
☛ Pre-manufacture and cryopreserve TIL seed cells from a patient's resected tumor tissue for future on-demand use.
☛ Rapid in vivo expansion and reaction after seed TIL infusion
☛ Significantly reducing manufacturing costs and production time.
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Robust
Reproducible performance across over 30 types of solid tumors.
Culture success rate >95%
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Competent
The average number of cells is approximately 20 billion,
IL-2 administration free
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Affordable
Substantial reduction in manufacturing costs and overall treatment costs
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Accessible
Patients treated in less demanding wards, and the time to reach discharge criteria is shortened
Clinical Trials
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A Phase II Trial of GC101 TIL in Advanced Melanoma(MIZAR-003)Beijing Cancer Hospital, Fujian Cancer Hospital, Fudan University Shanghai Cancer Center, Zhejiang Cancer hospital, Hunan Cancer Hospital, Henan Cancer Hospital, Cancer Hospital of Shandong First Medical University, etc.. -
A Phase Ib Trial of GC101 TIL in NSCLC(MIZAR-005)Shanghai Chest Hospital, Anhui Chest hospital, Hunan Cancer Hospital -
A Phase I Trial of GC203 TIL in Advanced Malignant Solid Tumors(KUNLUN-001)Fudan University Shanghai Cancer Center, Tianjin Medical University Cancer Institute & Hospital, Tenth People’s hospital of Tongji University, The Second Affiliated Hospital Zhejiang University School of Medicine, etc. -
A Phase I Trial of GC101 TIL in Advanced Malignant Solid TumorsChinese PLA General Hospital
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